Active Motif

Active Motif

Tools for Epigenetics, Chromatin Biology & Transcriptional Regulation

Active Motif is dedicated to enabling epigenetics research through developing innovative tools and reagents that help researchers investigate nuclear function with particular emphasis on chromatin dynamics and elucidating the mechanism and regulation of epigenetic events.

In addition to offering  validated antibodies and assays to enable the discovery and characterization of key epigenetic processes, such as histone modification and DNA methylation they also provide  complete service solutions for the genome-wide analysis of epigenetic events, including DNA methylation, histone modification and transcriptional regulation.


Antibodies to study epigenetics and gene regulation

High quality antibodies for studying epigenetics in the context of histone and DNA modifications. The antibodies are manufactured in-house, where they undergo rigorous developmental and validating procedures to ensure their quality and performance. The staff scientists have also validated these antibodies for use in applications such as chromatin immunoprecipitation (ChIP), ChIP-Seq, Western blot, and immunofluorescence. Active Motif’s antibodies are available in small scale and bulk quantities.


ChIP and ChIP-Seq products

A comprehensive line of products to support all steps in the ChIP workflow, including the largest range of kits and antibodies for ChIP and ChIP-Seq. Active Motif offers specialized kits for many sample types, including low cell numbers, transcription factors, FFPE tissue, PBMCs and many more.


Click here to see the ChIP kit selection guide


ATAC-Seq is based on transposase-mediated insertion of sequencing primers into open chromatin regions. This assay provides genome-wide profiles of open and accessible regions of chromatin that are indicative of active regulatory regions.


AbFlex® Recombinant Antibodies

AbFlex® antibodies are recombinant antibodies (rAbs) that have been generated using defined DNA sequences to produce highly specific, reproducible antibodies. Each AbFlex® antibody contains a Sortase recognition motif (LPXTG) to covalently add fluorophores, enzymatic substrates (HRP, AP…etc), peptides, DNA, drugs or other labels to the antibody in a directed and reproducible manner using Active Motif’s Sortag-IT Labeling Kits. Every antibody also contains a 6xHis tag, which can be used with nickel-based purification systems, and an avidin tag sequence for enzymatic biotin conjugation using the biotin ligase, BirA.


Nu.Q™ H3.1  

Histone H3.1, or the canonical form of Histone H3, is deposited during DNA replication and possibly also during repair. Study of H3.1 has identified cancer-associated mutations and differing affinities for the histone acetyltransferase HAT1. Active Motif’s Nu.Q™ H3.1 Assay Kit is designed for the detection of levels of Histone H3.1-containing, circulating cell-free nucleosomes (cf-nucleosomes) in human serum in a high-throughput format.


Recombinant Proteins

Active Motif offers a large collection of full-length, high quality recombinant proteins for many relevant drug targets. These proteins are manufactured to meet the highest standards of purity and activity required for conventional drug discovery assays, such as HTRF, mass spectrometry, AlphaLISA and Alphascreen, and these assays are routinely incorporated into the quality control processes. Active Motif also provides a wide selection of histone substrates and small molecules for your epigenetic drug discovery assays. The recombinant proteins are available in small scale and bulk quantities.


DNA methylation Products

Active Motif offers a wide variety of tools to study DNA methylation, including antibodies, kits, recombinant proteins, and services.


LightSwitch™ Luciferase Reporter Assay System

With a genome-wide library of over 30,000 pre-cloned and ready to transfect regulatory elements, a highly optimized Renilla luciferase (RenSP) vector system and assay reagents, the LightSwitch™ luciferase reporter assay system is the optimal solution for your gene regulation studies. Select from Active Motif’s wide range of products and services.


Epigenetics Services 

Custom chromatin and DNA methylation services. Genome-wide analysis using Next-Gen sequencing has significantly broadened the ability of scientists to understand epigenetic events. However, reproducibly generating high-quality, interpretable data from chromatin immunoprecipitation (ChIP) experiments can be challenging as it requires prior knowledge of working antibodies, optimized protocols for various cell types and knowledge of cell type-specific binding sites. Add in the technical and bioinformatics challenges associated with generating whole-genome data sets, and ChIP-Seq may literally be beyond your reach. Active Motif provides a wide variety of ChIP services. This makes it possible for you to utilize their research tools without having to be an expert in the techniques yourself.


* Prices listed on Active Motif’s website are in U.S. currency. For Australian pricing, please call our office, contact us at, or leave us a message for a quote here.


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    Product Name Product Number Supplier Size
    100 mM PMSF 37495 Active Motif VIEW DETAILS
    2′-Deoxy-5-fluorocytidine 14108 Active Motif VIEW DETAILS
    2′-Deoxy-5-fluorocytidine 14109 Active Motif VIEW DETAILS
    293 nuclear extract 36033 Active Motif VIEW DETAILS
    3-Methylcytosine (3-mC) antibody (pAb) 61111 Active Motif VIEW DETAILS
    3-Methylcytosine (3-mC) antibody (pAb) 61179 Active Motif VIEW DETAILS
    3-Methylcytosine (3-mC) antibody (pAb), sample 61112 Active Motif VIEW DETAILS
    3-Methylcytosine (3-mC) antibody (pAb), sample 61180 Active Motif VIEW DETAILS
    3T3-L1 nuclear extract 36071 Active Motif VIEW DETAILS