Cell Signaling Technology

Cell Signaling Technology

Antibodies, ELISA kits, ChIP kits, proteomic kits, and other reagents for study of the cell signaling pathways—particularly in the area of cancer research

Cell Signaling Technology (CST) is privately owned company, situated in Massachusetts; that is actively engaged in the development of new technologies for signaling analysis as well as mechanistic cell biology research. CST is also World leader in development of reagents and tools for regulatory post-translational modifications on proteins from human, mouse, and related species.

XP® Monoclonal Antibodies

XP® monoclonal antibodies are high quality rabbit monoclonal antibodies exclusively available from CST. XP® monoclonal antibodies are generated using a proprietary XMT® technology that provides access to a broad range of antibodies unattainable with traditional monoclonal technologies, allowing more comprehensive screening in the most relevant applications. Products labeled with XP have met additional standards for exceptional performance, including high specificity and sensitivity in one or more key applications and utility for multiple applications.

Antibody Sampler Kits

CST’s Antibody Sampler Kits include a range of targets to cover key cellular events, such as protein phosphorylation events or to assess various modifications within a specific pathway. Over 270 sampler kits complement research areas of cellular metabolism, DNA damage and cytoskeletal regulation.

PhosphoPlus® Antibody Duets

PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from CST’s product offering based upon superior performance in specified applications.

Application Solutions Kit for WB, IHC and IF

CST uses these reagents in their validation process, now you can too! From sample preparation to detection, everything you need for a more efficient and economical western blot, Immunohistochemistry or immunofluorescence application, is now found in one easy kit.

Control Cell extracts

These positive and negative control cell extracts and proteins are made and used in-house for antibody validation and lot to lot testing. For more information, please also see the controls table, which compiles cell lines and treatments that can be used as a positive control for our activation-state specific antibodies and serve as a reference for appropriately controlled experiments.

FastScan™ ELISA Kits

FastScan ELISA kits are similar in performance, sensitivity, and dynamic range as traditional ELISA but use solution-based sandwich ELISA method with fewer steps for faster time to results. These ready to go kits include identified optimal antibody to make sure your results are accurate across the lifetime of your discovery project – from target validation through preclinical phases.

PathScan™ ELISA Kits

PathScan® ELISA kits and reagents let you measure a wide range of key cell signaling proteins for your research and drug discovery campaigns. CST’s team has identified the antibody pairs with optimal activity in solid-phase ELISA and done the assay development and validation up front to make sure your results are accurate and consistent across the length of your project.

SignalSilence® – iRNA

SignalSilence® 4E-BP1 siRNA I from CST allows the researcher to specifically inhibit 4E-BP1 expression using RNA interference, a method whereby gene expression can be selectively silenced through the delivery of double stranded RNA molecules into the cell. All SignalSilence® siRNA products from CST are rigorously tested in-house and have been shown to reduce target protein expression by western analysis.

PTMScan – Proteomic Analysis products

PTMScan® Technology employs a proprietary methodology from CST for peptide enrichment by immunoprecipitation using a specific bead-conjugated antibody in conjunction with liquid chromatography (LC) tandem mass spectrometry (MS/MS) for quantitative profiling of post-translational modification (PTM) sites in cellular proteins. These include phosphorylation (PhosphoScan®), ubiquitination (UbiScan®), acetylation (AcetylScan®), and methylation (MethylScan®), among others. PTMScan® Technology enables researchers to isolate, identify, and quantitate large numbers of post-translationally modified cellular peptides with a high degree of specificity and sensitivity, providing a global overview of PTMs in cell and tissue samples without preconceived biases about where these modified sites occur. For more information on PTMScan® Proteomics Services, please visit https://www.cellsignal.com/services/index.html

* Prices listed on CST’s website are in U.S. Currency. For Australian pricing, please call our office or contact us at customerservice@aust-biosearch.com.au

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    Product Name Product Number Supplier Size
    (+)-JQ1 84566S Cell Signaling Technology 5 mg VIEW DETAILS
    0.5 M EDTA, pH 8.0 7011V Cell Signaling Technology 5 mL VIEW DETAILS
    10X Wash Buffer, Phosphate Buffered Saline (PBS) 12528S Cell Signaling Technology 200 mL VIEW DETAILS
    12-Tube Magnetic Separation Rack 14654S Cell Signaling Technology 1 ea VIEW DETAILS
    14-3-3 (pan) (E9S9M) Rabbit mAb 95422S Cell Signaling Technology 100 ul VIEW DETAILS
    14-3-3 (pan) Antibody 8312S Cell Signaling Technology 100 ul VIEW DETAILS
    14-3-3 beta/alpha Antibody 9636S Cell Signaling Technology 100 ul VIEW DETAILS
    14-3-3 epsilon Antibody 9635S Cell Signaling Technology 100 ul VIEW DETAILS
    14-3-3 eta (D23B7) Rabbit mAb 5521S Cell Signaling Technology 100 ul VIEW DETAILS