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Rewriting life - First Human Embryos Edited in U.S. Researchers have demonstrated they can efficiently improve the DNA of human embryos. The first known attempt at creating genetically modified human embryos in the United States has been carried out by a team of researchers in Portland, Oregon, MIT Technology Review has learned. The effort, led by Shoukhrat Mitalipov of Oregon Health and...
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Researchers at QIMR Berghofer have discovered a set of genes that could be used to predict the survival of breast cancer patients. The findings could in future help to determine which patients would benefit from additional treatments. The scientists, from QIMR Berghofer’s Control of Gene Expression research group, have also discovered one of the factors that can cause breast cancer to grow...
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An international research team has found a way to improve the anti-cancer effect of a new medicine class called ‘Smac mimetics’. The team discovered how a protein called MK2 helps to keep cancer cells alive, making them resistant to the anti-cancer effects of Smac mimetics. The findings provide a rationale for combining inhibitors of MK2 with Smac mimetics as a potentially powerful new...
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Like ivy plants that send runners out searching for something to cling to, the brain’s neurons send out shoots that connect with other neurons throughout the organ. A new digital reconstruction method shows three neurons that branch extensively throughout the brain, including one that wraps around its entire outer layer. The finding may help to explain how the brain creates...
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Engineering the elements of an antibody can create potential therapeutics—ones designed to be more effective and safer than ever. But this often requires optimization of not just selectivity and affinity for the given antigen, but also stability, solubility and immunogenicity of the antibody. The familiar Y-shaped structure includes a variable domain called the fragment antigen-binding (Fab)...
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